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NIH Seeks License, Collaborators for HPV-related Cervical Cancer miRNAs

NEW YORK (GenomeWeb News) – The National Institutes of Health has made available for licensing miRNA technology that could be used to develop a diagnostic or a therapeutic for cervical cancer tumors related to cases of human papillomavirus.
The NIH also said it is seeking statements of capability or interest from parties who may wish to engage in collaborative research to develop, evaluate, or commercialize the p53 specific miR-34, which it said is downregulated in HPV-infected primary keratinocytes. The miR-34 has been shown to arrest the cell cycle at a certain phase in tumor development and to promote apoptosis.
Information about the miRNA technology was published in 2007 in the July issue of Cancer Research and the Nov. 12 edition of Oncogene

The miRNA technology’s provisional application, number 60/983,368, was filed in October 2007, and its reference number is E-029-2008/0-US-01.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.