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NIH Looks to Outlicense Affinty Tag Removal, Fluorescence Detection Technologies

NEW YORK, Aug. 22 (GenomeWeb News) - The National Institutes of Health released today a listing of technologies it has made available for licensing, including one for removing affinity tags from fusion proteins and one related to fluorescence detection.


The first technology is an enzymatic reagent for removing C-terminal polyhistidine tags from recombinant proteins.


According to the NIH, the enzyme, MeCPA, is a carboxypeptidase that can "remove histidines and other amino acids from the C-terminus of proteins and could be used to remove affinity tags.  Because MeCPA will only digest disordered/unstructured residues, it could also be used to remove native amino acids from the C-terminus of proteins to facilitate crystallization."


Additional details about the technology can be obtained from Mojdeh Bahar at [email protected].


The second technology is a spatially selective fixed-optics multicolor fluorescence detection system for microfluidic devices, the NIH said.

The scheme available for licensing is sensitive spatially resolved and spectrally resolved laser-induced fluorescence detection from multiple microfluidic channels, the NIH said. A "prototype instrument has been developed and is versatile in that it contains only fixed optical parts and has simultaneous five-color detection from eight microchannels in a plastic microchip for DNA analysis.  The detection scheme could be applied to fluorescence detection for any microchip-based analysis in a transparent substrate."

The NIH licensing contact for this technology is Michael Shmilovich, who can be reached at [email protected]

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