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NIH Launches Program to Study Genetics and Genomics of Xenopus

NEW YORK, Sept. 26 (GenomeWeb News) - The National Institutes of Health has announced a new program entitled, "Genetic and Genomic Analyses of Xenopus," which is seeking new genetic and genomic tools "to exploit the power of Xenopus as a vertebrate model for biomedical research."


According to a program announcement issued last week, the NIH welcomes proposals "to develop new tools or genetic or genomic resources of high priority to the Xenopus community that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development, organogenesis, and in cell biological processes, such as cell division, signaling and migration."


In the program announcement, NIH outlined a number or resources that have already been developed for X. tropicalis and X. laevis, including cDNA libraries and EST sequences, UniGene clusters, full-insert cDNA clones and sequences, a genetic map, genomic libraries and genomic sequences, a physical map, microarrays, and transgenic and mutant animals. "These diverse data and reagents are being generated by investigators from several different research communities, including geneticists, gene sequencers, gene mappers, cell biologists, developmental biologists, and bioinformatics experts," NIH said, and  "can now be used to enhance Xenopus' role as a model system."


NIH said that it has not set aside any special funding for applications submitted in response to the announcement.


The anticipated start dates for new awards will be December, 2007, 2008, and 2009.


The first due date for letters of intent is Dec. 19, and the first due date for applications is Jan. 18, 2006.


"Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary," NIH said.

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