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NIH Awards $13.7M for Tuberculosis Structural Biology Project

NEW YORK, April 28 (GenomeWeb News) - The National Institute of Health has awarded $13.7 to a team headed by scientists at the Texas Agricultural Experiment Station to determine the three-dimensional structures of a "large number" of Mycobacterium tuberculosis proteins, Texas A&M said this week.  


The team will collaborate with researchers from the University of California, Los Angeles; the University of California, Berkeley; and Los Alamos National Laboratory.


The five-year project will use protein crystallography to identify potential drug-binding sites in M. tuberculosis proteins.


"We are taking a multi-discipline approach that will identify and characterize new drug targets that are essential for persistent M. tuberculosis," the researchers said the grant abstract in the NIH database. "Targets will be exposed to a battery of analyses including microarray experiments, bioinformatics, and genetic techniques to prioritize potential drug targets from [M. tuberculosis] for structural analysis."

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.