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NIH Awards $13.7M for Tuberculosis Structural Biology Project

Apr 28, 2006

NEW YORK, April 28 (GenomeWeb News) - The National Institute of Health has awarded $13.7 to a team headed by scientists at the Texas Agricultural Experiment Station to determine the three-dimensional structures of a "large number" of Mycobacterium tuberculosis proteins, Texas A&M said this week.  

 

The team will collaborate with researchers from the University of California, Los Angeles; the University of California, Berkeley; and Los Alamos National Laboratory.

 

The five-year project will use protein crystallography to identify potential drug-binding sites in M. tuberculosis proteins.

 

"We are taking a multi-discipline approach that will identify and characterize new drug targets that are essential for persistent M. tuberculosis," the researchers said the grant abstract in the NIH database. "Targets will be exposed to a battery of analyses including microarray experiments, bioinformatics, and genetic techniques to prioritize potential drug targets from [M. tuberculosis] for structural analysis."

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