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NIH To Award Up To $12M for Genome-wide Resequencing 'Pipeline'

NEW YORK (GenomeWeb News) - The National Institutes of Health plans to award up to $12 million over two years to develop a resequencing technology “pipeline” for genome-wide medical research.
 
The National Heart, Lung, and Blood Institute and the National Human Genome Research Institute plans to award between three and four grants under the program, according to a request for applications released on Friday.
 
The goal of the program is to “develop and validate a resequencing application for cost-effective, high-throughput sequencing of genome-wide medical targets by assembling current and emerging technologies in the areas of DNA target capture and sequencing,” NIH said in the RFA. 
 
The aim of the resequencing application “is to enable the sequencing of thousands of individual DNA samples in NHLBI’s well-phenotyped populations in a cost-effective manner.”
 
This “resequencing pipeline” could lower the cost of sequencing one percent of the genome to around $1,000, NIH said.
 
The targets for the sequencing programs are exons of the 20,000 protein-coding genes that are identified as RefSeq genes in the National Center for Biotechnology Information’s Entrez Gene database, which make up around 1 to 2 percent of the human genome.
These targets also could include other functional units such as microRNA and regulatory elements, NIH said.
 
Applications are due Feb. 28.
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