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NIGMS Awards GeneGo $750K SBIR Grant to Develop Drug Metabolism, Tox-Prediction Program

NEW YORK, Aug 8 (GenomeWeb News) - GeneGo of St. Joseph, Mich., has received a $750,000 phase II SBIR grant from the National Institute of General Medical Science to further develop its drug metabolism and toxicity prediction tool, MetaDrug, the company said today.

 

The amount of the grant was not immediately known. A call to GeneGo was not returned in time for this publication.

 

GeneGo said it plans to integrate predictive algorithms for ADME/Tox properties into MetaDrug, add a database of ligand-protein interactions from other species than humans, develop in vitro datasets for drug interactions with key human cytochrome P450s, and integrate a novel algorithm for metabolite prediction.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.