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NIEHS, Perlegen Publish SNP Database, Haplotype Map for 15 Mouse Strains

NEW YORK (GenomeWeb News) — The National Institute of Environmental Health Sciences and Perlegen Sciences have published results from mouse genome-resequencing and genomic-analysis studies that can be used to link genes to environmental diseases, the National Institutes of Health said today.
In the study, scientists at Perlegen used Affymetrix oligonucleotide arrays to resequence four wild-type and eleven “classical” mouse strains and identify 8.27 million SNPs across the 15 strains.
The NIH said the arrays queried around 1.49 billion of the 2.57 billion base pairs of the C57BL/6J mouse reference strain, and the resulting data was used to create the 41,000-segment haplotype map.
“These data allow researchers to compare the genetic makeup of one mouse strain to another, and perform the necessary genetic analyses to determine why some individuals might be more susceptible to disease than another,” David Schwartz, director of the NIEHS, said in a statement.
The results of the Mouse Genome Resequencing and SNP Discovery Project appear in the July 29 issue of Nature, while haplotype maps providing data from these studies are available on the National Center for Biotechnology Information’s website and a site hosted by Perlegen.
Schwartz said the information will be “a valuable resource” for the National Toxicology Program, which is an interagency program based out of the NIEHS.
“We also hope that pharmaceutical companies developing new treatments for environmental diseases will find these data and this paper as a valuable resource,” Schwartz added.

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