NEW YORK (GenomeWeb News) – The National Institute of Allergy and Infectious Diseases will give $20 million next fiscal year to fund projects focused on creating a network that will use systems biology, proteomics, transcriptomics, and a range of other approaches to study human immune responses.
Funded under the American Recovery and Reinvestment Act, the "Protection of Human Health by Immunology and Vaccines" grants will fund collaborative projects, pilot projects, infrastructure, and new research opportunities.
NIAID expects that for U01 grants it will award up to $1.5 million in total costs in the first year and $1.3 million in years two through five, and for U19 grants it will award up to $4.5 million in the first year and up to $4 million in years two through five.
NIAID is seeking applications that will study human immune responses after infection, prior to and following vaccination against infectious disease, and before and after treatment with an immune adjuvant that targets innate immune receptors.
The goal is to use recent advances in immune profiling to measure the diversity of immune responses under a variety of conditions, and will use bioinformatic, multiplex, or systems biology approaches to study samples and to measure aspects of the human transciptome or proteome.
The awardees will establish a research infrastructure to collect, characterize, and store human samples, and they will work with other award winners to build resources for use by all the investigators.
These research programs may propose a variety of research approaches, including cross-disciplinary activities, such as genome-wide association studies seeking genetic polymorphisms relevant to vaccination and infection; epigenetic studies relevant to human responses to vaccination and/or infection; development of tools to manage and analyze large data sets resulting from human immune profiling studies; and several other research areas.