NEW YORK (GenomeWeb News) — The National Institute on Alcoholism and Alcohol Abuse is seeking research into how genetic variants may be linked to alcohol dependence in adults and adolescents.
NIAAA expects to give a cooperative agreement award of up to $6.8 million, and is soliciting investigators currently supported under the existing Collaborative Study of Genetics of Alcoholism.
These studies will determine molecular and functional mechanisms of variants, identify and characterize gene and environment interactions leading to alcoholism, and develop and refine phenotypes that will help facilitate genetic analysis.
NIAAA said in a funding announcement that it is interested in the following research areas:
- Studies that aim to replicate candidate gene findings from statistical association analyses.
- Molecular and functional studies to understand how genes identified by statistical association analyses contribute to risk, protection, or variation in alcohol-related phenotypes.
- Studies of young adults in the COGA sample to examine genetic effects across development and to determine factors affecting risk.
- Studies that explore how specific alleles that affect risk manifest themselves as adolescents and young adults pass through ages of risk for developing alcohol dependence.
- Genetic analysis studies to detect gene and environment interactions that contribute to risk, protection, or variation.
- Studies that incorporate prospective studies of COGA probands using candidate polymorphisms from GWAS.
More information about the COGA-limited competition is available here.