Skip to main content
Premium Trial:

Request an Annual Quote

NIA to Fund Gene, Phenotype Studies on Long Lives

NEW YORK (GenomeWeb News) – The National Institute on Aging will spend nearly $10 million over the next three years on research that aims to discover genetic and other characteristics of families in which some people are more likely to live to be extremely old and who have maintained good health throughout most of their lives.

The second phase of the multi-center Long Life Family Study will support research for up to three years, including $5.2 million in 2010, $2.7 million in 2011, and $1.7 million in 2012, and will pick up from the earlier phase of the program, which developed comprehensive protocols, recruited families, and collected specimens.

The LLFS was designed to determine the degree and patterns of familial transmission and aggregation of exceptional longevity and healthy survival to advanced age by using phenotypic and genetic factors.

This research will include genetic analysis of DNA samples collected in the first phase, genome-wide scans, re-sequencing, and other methods for discovering genetic variants linked to health and advanced aging.

It also will include support for long-term storage of biospecimens, data sharing, and analysis of genetic and phenotypic data.

Filed under

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.