The NHLBI said it plans to award $24.3 million over the next five years to support nine new cluster grants, three in each of the next three years, focused on developing systems biology approaches to "explaining and predicting complex cellular and physiological phenomena of living organisms in terms of underlying physical and chemical processes and accompanying feedback regulations at molecular, cellular, tissue, or whole organ levels" in the context of heart, lung, blood, and sleep physiology and pathophysiology.
Examples of research topics that fall under this request include, but are not limited to: networks involved in regulating oxygen delivery, including regulation of hemoglobin levels though control of red cell production, changes in vascular tone, and regulation of distribution of blood flow in different vasculatures; electrical and structural simulations of the heart, including expression of ion channel genes, that predict occurrence of arrhythmias and responses to potential treatments; and the role of inflammation in the development of pulmonary, thrombotic, and cardiovascular diseases and responses to pharmacological intervention, targeting NSAID therapy.
Letters of intent are due by Feb. 8, 2006, with final applications due by March 10, according to the NHLBI. The RFA expires on March 11. Additional details about the funding opportunity can be found here.