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NHLBI to Issue RFP for Large-Scale Genotyping Center

NEW YORK, March 21 (GenomeWeb News) - The National Heart, Lung, and Blood Institute will begin soliciting proposals in early April for the creation of a Large-Scale Genotyping Center that will perform high-throughput genotyping for candidate gene association studies and a genome-wide association study.    


NHLBI expects to award one four-year contract for the center, and said in a presolicitation notice that the RFP should be available here "on or about" April 4.


Proposals will be due in early July. NHLBI did not disclose the expected amount of funding for the center.


NHLBI said the center is necessary "to expand the utilization of NHLBI's well-phenotyped observational cohorts and intervention studies for genetic association studies, through the application of large-scale genotyping and widespread data dissemination for genotype-phenotype correlation."


The center "must have the capacity to generate at least 850 million genotypes over two years with an error rate of no more than 1 percent," NHLBI said in the presolicitation notice. NHLBI has set a maximum cost of $0.01 per genotype, which is expected to "decrease as technologies evolve."


The proposed candidate gene association studies will involve the characterization of more than 1,700 candidate genes, with 8-10 SNPs per gene region, on approximately 50,000 study members in heart, lung, blood, and sleep studies. The study is expected to result in more than 850 million genotypes. 


The genome-wide association study, to be implemented in the second year of the program, will involve a set of up to 300,000 genetic variants in around 500 cases and 1,000 controls, for a total of around 450 million genotypes.

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