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NHGRI Awards OriGene SBIR Grant to Clone 400 Large Genes

NEW YORK, Sept. 22 (GenomeWeb News) - The US National Institutes of Health National Human Genome Research Institute awarded OriGene Technologies a phase I Small Business Innovation Research grant to isolate 400 very large full-length genes for addition to its TrueClone collection, the company said today in a statement.


Proteins encoded by large transcripts play important roles in cell-cell interaction, signal transduction, intracellular transportation, structural organization and regulation of nucleotide and protein metabolism, said Zairen Sun, OriGene vice president of molecular biology. Positioning cloning also indicated that genes associated with various genetic diseases tend to encode large proteins, "such as BRCA1 and BRCA2 for breast cancer," he added.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.