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NHGRI Awards OriGene SBIR Grant to Clone 400 Large Genes

NEW YORK, Sept. 22 (GenomeWeb News) - The US National Institutes of Health National Human Genome Research Institute awarded OriGene Technologies a phase I Small Business Innovation Research grant to isolate 400 very large full-length genes for addition to its TrueClone collection, the company said today in a statement.


Proteins encoded by large transcripts play important roles in cell-cell interaction, signal transduction, intracellular transportation, structural organization and regulation of nucleotide and protein metabolism, said Zairen Sun, OriGene vice president of molecular biology. Positioning cloning also indicated that genes associated with various genetic diseases tend to encode large proteins, "such as BRCA1 and BRCA2 for breast cancer," he added.

The Scan

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.

Study Reviews Family, Provider Responses to Rapid Whole-Genome Sequencing Follow-up

Investigators identified in the European Journal of Human Genetics variable follow-up practices after rapid whole-genome sequencing.

BMI-Related Variants Show Age-Related Stability in UK Biobank Participants

Researchers followed body mass index variant stability with genomic structural equation modeling and genome-wide association studies of 40- to 72-year olds in PLOS Genetics.

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.