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Next-Gen Tomorrow's PIs


We asked the young investigators profiled in last year’s special edition of Genome Technology to tell us whom they see as the really promising, really young investigators — for the most part, students who are still working on their advanced degrees.  Here they are.

Name: David P. Chen
Affiliation: Stanford University Center for Biomedical Informatics Research
Recommended by: Atul Butte
Research: David Chen is currently pursuing his PhD in biomedical informatics at Stanford University. He is focused on novel translational approaches and data integration methods to better identify biomarkers.

Name: Carolin Graebsch
Affiliation: Helmholtz Centre for Environmental Research, Department  of Human Exposure Research and Epidemiology
Recommended by: Holger Kirsten
Research: Carolin Graebsch is concentrating on the joint analysis of environmental risk factors and genetic risk factors for airway diseases, allergies, and metabolic dysfunctions. Graebsch is also investigating the methodology of conducting epidemiological, individual-oriented empirical studies.

Name: David Hughes
Affiliation: Max-Planck-Institute for Evolutionary Anthropology, Department of Evolutionary Genetics
Recommended by: Holger Kirsten
Research: David Hughes is looking to identify regions of the genome that have a signature of local selection. Hughes and his colleagues are using genome scans and public databases as screening tools to identify interesting genomic regions.

Name: Adam Margolin
Affiliation: Columbia University, Department of Biomedical Informatics
Recommended by: Adolfo Ferrando
Research: Adam Margolin is a PhD student researching ways to engineer in vivo nanocomputers capable of identifying and then eradicating cancer cells. He is also developing statistical methods to identify genetic regulatory networks involved in cancer cell growth.

Name: Tarjei Mikkelsen
Affiliation: The Broad Institute
Recommended by: Bradley Bernstein
Research: Tarjei Mikkelsen splits his research between comparative genomics — including bug, dog, and possum genome projects — and epigenetics, where he is working on technologies that can identify histone modifications across an entire genome. He is focused on understanding how the cell uses histone methylation and how abnormal modifications can contribute to cancer and other human diseases.

Name: James Ronald
Affiliation: University of Washington, Genome Sciences
Recommended by: Joshua Akey
Research: James Ronald is interested in defining the role that mRNA decay plays in gene expression. Ronald conducts genome-wide comparisons of mRNA decay rates in Joshua Akey's lab at UW in the genome sciences department, where he uses different strains of yeast as a model system.

The Scan

Ancient Greek Army Ancestry Highlights Mercenary Role in Historical Migrations

By profiling genomic patterns in 5th century samples from in and around Himera, researchers saw diverse ancestry in Greek army representatives in the region, as they report in PNAS.

Estonian Biobank Team Digs into Results Return Strategies, Experiences

Researchers in the European Journal of Human Genetics outline a procedure developed for individual return of results for the population biobank, along with participant experiences conveyed in survey data.

Rare Recessive Disease Insights Found in Individual Genomes

Researchers predict in Genome Medicine cross-population deletions and autosomal recessive disease impacts by analyzing recurrent nonallelic homologous recombination-related deletions.

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.