The hype around next-gen sequencing is at fever pitch. And while in many ways that's actually deserved with tools that promise to be as revolutionary as these do, it's worth remembering that this technology isn't a good fit for every lab. Though genome centers are amassing fleets of next-gen instruments, some users say that smaller labs might be better off using a service or finding a core facility than investing in the technology themselves.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.