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New Lab & IT Products for Integrated Biology: Apr 1, 2005

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BIOINFORMATICS

Gene Logic Genesis Enterprise System 2.5

Version 2.5 of Gene Logic’s Genesis Enterprise System further expands and accelerates researchers'' ability to assess drug risks using genomics and toxicogenomics data and related clinical information. Users can now use the software to import and analyze their own Affymetrix GeneChip array data and annotate their samples. The latest software update reflects significant customer input regarding group-share abilities for a collaborative, secure environment and visualization tools for rapid, simultaneous examination of expression data and clinical attributes.

Gene Logic

800.GENE.LOGIC

www.genelogic.com

Lion Bioscience SRS Version 8.1

Version 8.1 of SRS has been enhanced with a redesigned search interface and new Related Information Browser, which automatically links search results in SRS to related information. LION has also expanded its range of Linux-supported platforms for SRS. The SRS data integration platform provides integrated access to all life science data.

Lion Bioscience

+44 1223 224747

www.lionbioscience.com/srs

MultiQTL v. 2.5 Gene Mapping Software

MultiQTL software integrates a broad spectrum of data mining, statistical analysis, interactive visualization, and modeling tools that allow QTL analysis based on advanced and sophisticated methods for maximum extraction of the mapping information from data. This includes tools for multilocus, multiple-trait, and multiple-environment QTL analysis in controlled crosses of economically important plants and animals, as well as model organisms.

MultiQTL

+972-48240-449,

http://esti.haifa.ac.il/~poptheor/MultiQtl/MultiQtl.htm

Nonlinear Dynamics TotalLab Now Mac Compatible

TotalLab, Nonlinear’s general image analysis software, is now compatible with the Apple Mac by using Virtual PC for Mac v7.0. The core component of the software is the comprehensive 1D analysis module, which is simple to use and allows a fast and consistent analysis of 1D gel electrophoresis images in a few clicks. TotalLab also includes three additional modules, for the quantitative analysis of arrays, colonies, and a toolbox for general image analysis.

Nonlinear Dynamics

+44 (0)191 230 2121

www.nonlinear.com

Spotfire DecisionSite Version 8.1

Version 8.1 of Spotfire’s DecisionSite visual analysis software puts more of DecisionSite''s interactive capabilities on the Web, allowing for wider sharing of analysis results among researchers throughout the drug discovery chain. DecisionSite Posters allows researchers to share results — from gene expression dendograms to drug safety signal detection — in one online application that now supports heat maps, bar charts, pie charts, trellising, and text search.

Spotfire

800 245.4211

www.spotfire.com

 

BIOLOGICAL ASSAYS

BD Biosciences Clontech ZsGreen Fluorescent Protein Vectors

The pIRES2-ZsGreen1 vector contains an internal ribosome entry site, which permits both the cloned gene and the ZsGreen1-encoding region to be translated from a single mRNA. ZsGreen1 fluorescence intensity directly correlates with the expression level of your gene of interest. The pZsGreen1-1 is a promoterless vector for studying transcriptional regulation.

BD Biosciences Clontech

877.232.8995

www.bdbiosciences.com

BioSource Multiplex Mouse Cytokine and Chemokine Detection Kit

This antibody 20-plex kit from BioSource allows precise quantification of mouse IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40/p70, IL-13, IL-17, IFN-g, IP-10, FGF-b, GM-CSF, MCP-1, MIP-1a, MIG, RANTES, TNF-a, and VEGF from just 50 mL of either serum or cell culture supernatant. Designed for use with the Luminex system.

BioSource

800.242.0607

www.biosource.com

Genpathway TranscriptionPath, FactorPath, and PromoterPath

Rather than measure RNA levels, Genpathway’s TranscriptionPath, FactorPath, and PromoterPath tools measure levels of transcription machinery; including differential gene transcription, components and processes for gene regulation, and corresponding genetic pathways. TranscriptionPath is designed for identifying and quantifying of gene transcription based on isolation and characterization of DNA/transcription machinery complexes; FactorPath for the discovery and quantification of binding by transcription factors and coactivators; and PromoterPath for the identification of promoters and enhancers, and quantification of their use.

Genpathway

858.457.6898

www.genpathway.com

Stratagene ElectroTen-Blue Electroporation-Competent Cells

The ElectroTen-Blue cells are designed to transform large DNA molecules with high efficiency. The cells exhibit the high electroporation efficiency (Hee) phenotype. The Hee phenotype improves survival of these cells during electroporation treatment, dramatically improving transformation efficiency. The high cloning efficiency makes this strain an ideal host for generating large, more representative libraries.

Stratagene

800.424.5444

www.stratagene.com

Stratagene PathDetect Cis-Reporting Systems

The PathDetect cis-reporting systems were designed for rapid and convenient assessment of the in vivo activation of enhancer element pathwas. Each cis-reporter plasmid contains the luciferase reporter gene driven by a basic promoter element (TATA box) joined to tandem repeats of AP-1, CRE, SRE, ISRE, GAS, NFAT, NF-kB, p53, SRF, or TARE binding elements. The cis-reporting plasmids can also be used to evaluate uncharacterized genes, growth factors, drug candidates, or the effects of extracellular stimuli.

Stratagene

800.424.5444

www.stratagene.com

Stratagene SignalScout Phosphatase Profiling System

The new SignalScout phosphatase profiling system allows researchers to study dephosphorylation by 39 protein tyrosine phosphatases. This system will include three types of products: a) tagged human phosphatase expression clones for mammalian expression, b) tagged substrate trapping mutant human phosphatase expression clones matched to each phosphatase, and c) purified GST-tagged phosphatases (enzymatically active either as a full-length construct, a truncated protein, or a catalytic domain).

Stratagene

800.424.5444

www.stratagene.com

 

IMAGING

Thermo Electron OMNIC Atlus 7.2 Imaging Software for Infrared and Raman Microspectroscopy

Version 7.2 of the Atlus imaging software from Thermo Electron now provides a complete imaging solution for infrared and Raman microscopes with the addition of content analysis of both video and chemical images for particle dimensions and advanced image statistics. Images can also be reproduced through the added ability to pull information from the software''s history, allowing users to easily recreate an image from raw data and processing steps. Spectral statistics allow users to group spectra and perform advanced statistics, as well as employ Principal Component Analysis to minimize the spectral contribution of undesired features while improving the signal to noise and the spatial resolution of the overall set of data.

Thermo Electron

800.532.4752

www.thermo.com/spectroscopy

 

LIQUID HANDLING

BD FACSArray Bioanalyzer

The BD FACSArray bioanalyzer is a new platform for fast and sensitive high-content analysis of proteins in cell biology, immunology, and proteomics. Capable of both multiplexed bead and cellular assays, the BD FACSArray bioanalyzer is a platform that is easy to use, yet flexible and sensitive.

BD Biosciences Pharmingen

877.232.8995

www.bdbiosciences.com

Beckman Coulter P50 Liquid Handling Tips

Designed for use with Beckman’s Biomek 3000, NX, and FX Multimek liquid handlers, these new narrow-length tips enable pipetting from the bottom of deep labware for maximum retrieval of valuable samples. The disposable, non-conducive P50 Tips are ideal for work in both 96- and 384-well formats in applications such as compound library profiling and assay development, MALDI-TOF plate spotting, sample pooling, plate replication, and hit picking. The new tips pipette a volume of 50 µl with barrier and are certified to be Rnase/Dnase-free.

Beckman Coulter

800.742.2345

www.beckmancoulter.com

 

MICROARRAY ANALYSIS

Agilent Technologies Whole Rat Genome Oligonucleotide Microarray

With probes for more than 41,000 unique genes and transcripts, the Agilent Whole Rat Genome Oligo Microarray features highly sensitive 60-mer oligonucleotide probes, which allow increased detection of low-expressing, or rare, genes. Agilent''s microarray probes are based on recently released sequence information from the public genome databases RefSeq, UCSC GoldenPath, Ensembl, Genbank LocusLink, Homolgene, and UniGene.

Agilent Technologies

800.227.9770

www.agilent.com

 

PCR

Bio-Rad Laboratories iScript Select cDNA Synthesis Kit

This new reverse transcription system is optimized for reliable cDNA synthesis using from 1 µg down to as little as 1 pg of input RNA. This sensitive and flexible reverse transcription kit includes an optimized section of primers, providing researchers with the ability to use any first-strand priming approach. The flexible format of this kit is appropriate for a variety of applications including RT-PCR and real-time RT-PCR. In addition, this kit is quality controlled for the synthesis of cDNA fragments greater than 6 kb in length, making it appropriate for applications such as cloning.

Bio-Rad

800.4.BIORAD

www.bio-rad.com/amplification/

 

PROTEOMICS

Agilent Technologies HPLC Chip/Mass Spectrometry System

Smaller than a credit card, Agilent''s Protein ID HPLC-Chip for protein identification integrates sample enrichment and separation capability of a nanoflow LC system with the intricate connections and spray tips used in electrospray mass spectrometry. To enable compliance and experiment management, the HPLC-Chip includes a radio frequency tag that contains information such as chip ID and type, documentation, diagnostic, and operational data. The HPLC-Chip/MS Cube interface, which is mounted on Agilent''s Nanoflow Proteomics Solution XCT+ Ion Trap mass spectrometer, positions the sprayer tip orthogonal to the MS inlet to achieve maximum sensitivity and robustness, as well as automatically loads and seals the chip.

Agilent Technologies

800.227.9770

www.agilent.com

GeneBio Updated Phenyx Mass Spectrometry Analysis Software

The latest release of Phenyx, GeneBio’s protein identification platform, now incorporates the mzData standard and improves the results comparison functionality for all versions of Phenyx. A host of other features have also been added, including enhanced installer functionality for the standalone platform. Additionally, researchers can import results from other major software packages, such as Mascot and SEQUEST, in order to cross-validate or consolidate their identification results through the complementary use of several software packages.

GeneBio

+41 22 702 99 00

www.phenyx-ms.com

GWC Technologies SPRimager II Detection System

Designed for label-free analysis of protein and other molecular arrays, the SPRimager II relies on Surface Plasmon Resonance (SPR) for detection. The SPRimager II may be used to monitor protein-protein interactions as well as interactions involving DNA, RNA, carbohydrates, and ligands.

GWC Technologies

608.441.2722

www.gwctechnologies.com

Thermo Electron Finnigan Surveyor Plus HPLC System

The Finnigan Surveyor Plus HPLC system features an integrated column oven and the ability to use vials or plates. Thermo’s patented LightPipe technology ensures superior sensitivity, up to five times higher than that of conventional photo diode array detectors. The high-throughput Finnigan Surveyor Plus integrates seamlessly with the Finnigan Surveyor MSQ Plus.

Thermo Electron

800.532.4752

www.thermo.com/chromatography

Thermo Electron 1.9 µm Hypersil GOLD HPLC Column

Due to its smaller particle size, the new 1.9 µm particle size Hypersil GOLD HPLC column allows higher efficiency and improved peak capacity, enabling accurate detection and quantification of lower concentrations of analytes. Designed primarily for applications in pharmaceutical and proteomics research, the columns are available in 20, 30, and 50 mm lengths and 2.1 to 4.6mm ID, as well as 10 and 20 mm Javelin columns.

Thermo Electron

800.532.4752

www.thermo.com/columns

To tell GT about new recently released products, e-mail John MacNeil, Senior Editor, at [email protected]

 

The Scan

Renewed Gain-of-Function Worries

The New York Times writes that the pandemic is renewing concerns about gain-of-function research.

Who's Getting the Patents?

A trio of researchers has analyzed gender trends in biomedical patents issued between 1976 and 2010 in the US, New Scientist reports.

Other Uses

CBS Sunday Morning looks at how mRNA vaccine technology could be applied beyond SAR-CoV-2.

PLOS Papers Present Analysis of Cervicovaginal Microbiome, Glycosylation in Model Archaea, More

In PLOS this week: functional potential of the cervicovaginal microbiome, glycosylation patterns in model archaea, and more.