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New Lab & IT Products for Integrated Biology: May 1, 2005

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BIOINFORMATICS

Microway WhisperStation Workstation

Designed for 64-bit compute-intensive applications, the WhisperStation standard configuration features dual AMD Opteron or Intel Xeon EM64T processors, an NVIDIA FX1300 PCI Express Graphics engine, 2GB memory, ultra-quiet fans and power supply, and a Viewsonic 20" LCD monitor. Microway also says the low noise system provides a soothing supercomputing experience, and is available with a 64-bit Linux or Windows operating system.

Microway
www.microway.com
508.746.7302

Tripos AUSPYX 1.6 Data Cartridge

Built on Oracle’s extensibility architecture, the AUSPYX 1.6 data cartridge from Tripos enables storage and searching of chemical structures and associated relational data within Oracle environments. Developed and validated in collaboration with pharmaceutical partners, the data cartridge provides a core framework upon which to build high-performance cheminformatics applications such as reagent selection systems and virtual HTS systems.

Tripos
800.323.2960
www.tripos.com

 

BIOLOGICAL ASSAYS

BellBrook Labs Transcreener UGT Assay

For use in high-throughput screening, the Transcreener universal UDP glucuronosyltransferase (UGT) assay enables screening of all UGT isoforms and diverse acceptors using the same assay and reagents. This fluorescence polarization assay measures UDP formed during UGT- catalyzed glucuronidation reactions. As UDP is produced, the AlexaFluor488-labeled tracer is displaced from the antibody which decreases polarization.

BellBrook Labs
866.313.7881
www.bellbrooklabs.com

 

DNA SEQUENCING

Beckman Coulter GenomeLab Methods Development Kit

A complement to Beckman Coulter''s CEQ Quick Start and DTCS kits, this new kit contains a set of core reagents plus a choice of nucleotide mixtures — dITP for routine sequencing and dGTP for sequencing through difficult G-C rich and polymerase hard stop regions. The dGTP chemistry is highly effective for those problematic templates where standard terminator kits produce data with early signal loss.

Beckman Coulter
800.742.2345
www.beckmancoulter.com

 

IMAGING

Kodak Image Station 4000 Digital Imaging System

Designed for comprehensive fluorescence, luminescence, radiographic and chromogenic imaging applications, the Image Station 4000 features a 4 million pixel CCD and 10x optical zoom lens provides spatial resolution of up to 10 microns/pixel. True 16-bit imaging provides highly accurate grayscale resolution and broad linear dynamic range for quantitative imaging of membranes, electrophoresis gels, plates, tissues, and in vivo assays.

Eastman Kodak
877.SIS.HELP
www.kodak.com/go/imagestation

Thermo Electron SpectraCorr 2D Correlation Spectroscopy Software

Designed for use with FT-ICR analysis, the SpectraCorr 2D correlation spectroscopy (2DCOS) software combines the latest development in 2DCOS algorithms and advanced imaging graphics. The software provides additional data processing options and multiple display modes for spectral correlation and profiling analysis. It also enhances spectral resolution and detailed elucidation of the dynamic behavior of spectral intensity variation in a perturbation-dependent dynamic system, particularly with the analysis of the generalized 2D contour maps.

Thermo Electron
800.532.4752
www.thermo.com

 

MICRO RNA ANALYSIS

US Genomics Trilogy 2020 Single Molecule Analyzer

The Trilogy 2020 Single Molecule Analyzer is a bench-top platform composed of instrumentation, reagents, and software, designed to directly detect and quantitate individual molecules without amplification. The initial application for the Trilogy 2020 Single Molecule Analyzer is for the direct detection of microRNA molecules. The instrument accommodates 96- and 384-well plates and can process up to 2000 biological samples per day.

US Genomics
781.937.5550
www.usgenomics.com

 

MICROARRAY ANALYSIS

Illumina Sentrix Human-6 and HumanRef-8 Beadchips

The two new Sentrix beadchips from Illumina enable whole-genome and RefSeq-based expression profiling of multiple samples on the same microarray. The Sentrix Human-6 BeadChip is designed to analyze six discrete human RNA samples on one chip, interrogating in each sample over 46,000 transcripts from the human genome. The Sentrix HumanRef-8 BeadChip can query eight samples in parallel against 23,000 transcripts derived from genes represented in the consensus RefSeq database.

Illumina
800.809.4566
www.illumina.com

Quantum Dot Mosaic Gene Expression Assay System

Designed to measure quantitative expression of 100 user-specified mRNAs simultaneously from small amounts of input sample, the Mosaic system includes the Mosaic Q1000 scanner and computer, Mosaic software, and custom gene panels configured in convenient kit format; the assay is designed for automated processing on liquid-handling workstations. Each custom Gene Panel is designed and manufactured with gene-specific beads that are spectrally coded with the QDC''s innovative Qdot nanocrystals.

Quantum Dot
510.887.8775
www.qdots.com

Stratagene SpotReport Alien Oligo Array Validation System

The SpotReport alien oligo array validation system is a group of controls that collectively validate experimental parameters for oligo-based plant, animal, or microbial microarrays. A carefully selected set of 10 artificial sequences and corresponding RNA spikes lets you normalize data and allows data comparisons within and between microarray experiments. Other standard controls include Human ß-actin, polyA, and COT-1 DNA, all provided in a convenient ready-to-spot format.

Stratagene
800.424.5444
www.stratagene.com

 

PCR

BD Biosciences Clontech Qtaq ROX-free DNA Polymerase Kit

The Qtaq ROX-free DNA polymerase kit is designed for high efficiency and yield in qPCR reactions. Because the ROX dye is provided separately, the kit allows researchers to determine the best passive reference dye concentration for the experiment or to omit ROX altogether.

BD Biosciences Clontech
www.bdbiosciences.com
877.232.8995

Epicentre FailSafe PROBES Real-Time PCR Optimization Kit

Designed for one-step optimization of individual or multiplex real-time PCR assays, Epicentre’s new FailSafe PROBES real-time PCR optimization kit, for use with target-specific probes, enables fast and easy optimization of efficiency and specificity in just one round of PCR experiments. The FailSafe PROBES Optimization kit contains EPICENTRE’s FailSafe Enzyme Blend and a set of 8 specially-chosen PCR 2X PreMixes that represent a complete range of PCR conditions.

EPICENTRE Biotechnologies
800.284.8474
www.epibio.com

 

PROTEOMICS

Agilent Technologies mRP-C18 LC Column

The new Agilent macroporous reversed-phase C18 (mRP-C18) high-recovery protein fractionation and desalting LC column enables proteomics researchers to more efficiently detect and identify potential biomarkers in complex samples such as serum or plasma by providing high sample recovery (greater than 95 percent), resolution and reproducibility. Up to 380 micrograms of total protein mass can be loaded onto the 4.6 x 50 mm reusable column at once, without any reduction in resolution.

Agilent Technologies
800.227.9770
www.agilent.com/chem/bioreagents

Applied Biosystems 3200 Q TRAP and API 3200 LC/MS/MS Mass Spectrometers

By incorporating the Applied Biosystems/MDS SCIEX Turbo V source and API 4000 LC/MS/MS System-series interface and ionization sources into a smaller platform, these new systems provide increased sensitivity, greater flexibility, and improved ease-of-use when compared to comparably priced instruments. The ceramic interface of the API 3200 and 3200 Q TRAP LC/MS/MS Systems reduces chemical background and improves sensitivity under LC conditions, yielding better efficiency, relative to older source technologies, especially at higher flow rates.

Applied Biosystems
800.327.3002
www.appliedbiosystems.com

Beckman Coulter ProteomeLab Partitioning Systems and Chemistries

This new family of ProteomeLab partitioning systems and chemistries provides advanced sample preparation for the isolation and analysis of protein-based biomarkers. The first product in this new line is the ProteomeLab IgY-12 Proteome Partitioning Chemistry. Based on avian-generated antibodies bound to inert beads, ProteomeLab IgY-12 liquid chromatography and spin columns selectively partition the 12 most abundant proteins — up to 96 percent of the protein mass — from human serum or plasma.

Beckman Coulter
800.742.2345
www.beckmancoulter.com

GWC Technologies SpotReady Chips for Proteomics

Designed to work with GWC’s SPRimager and SPRimagerII surface plasmon resonance systems, the SpotReady chips allow researchers to detect molecular interactions on arrays without the use of fluorescent or other molecular labels. SPR arrays make possible simultaneous analysis of multiple samples under identical conditions in real time. The special glass SpotReady chips are coated with a hydrophobic background, and each chip has 16 or 25 gold spots in a grid pattern for probe attachment.

GWC Technologies
608.441.2722
www.gwctechnologies.com

Thermo Electron Open Access and Discovery for Xcalibur 1.4 SR1

Thermo’s Open Access and Discovery software applications are now available for the company’s Xcalibur 1.4 SR1 mass spectrometry data system. These applications can be used with any Finnigan ion trap or quadrupole mass spectrometer, as well as with liquid chromatography systems released for Xcalibur 1.4 SR1. The software enables seamless operation of multiple instruments on one open access system and automates routine analysis.

Thermo Electron
800.532.4752
www.thermo.com/ms

 

SAMPLE PREP

Epicentre Biotechnologies ExtractMaster Fecal DNA Isolation Kit

The New ExtractMaster Fecal DNA Isolation Kit is designed to recover PCR-ready DNA from the feces of a variety of animals. The kit utilizes a detergent lysis process combined with a chromatography step, which removes enzymatic inhibitors that often co-extract with DNA from such samples. The extracted DNA is PCR-ready, and can be used with the Epicentre FailSafe PCR System to amplify bacterial, protist, or animal templates.

Epicentre Biotechnologies
www.epibio.com
800.284.8474

Epicentre PlasmidMAX DNA Isolation Kit

The PlasmidMAX DNA isolation kit provides all of the reagents necessary to purify plasmids free of RNA and genomic DNA. The procedure requires only two 1.5 ml tubes, thus avoiding excess plasticware waste, and the resulting high-quality DNA permits sequencing reads of at least 600 bases. No spin columns or other specialized equipment are required.

Epicentre Biotechnologies
www.epibio.com
800.284.8474

Nanostream Integrated Plate Changing System

Nanostream’s new integrated plate changing system is designed for use with the Veloce micro parallel liquid chromatography system. The plate changing system automates the exchange of microwell plates for use with the Veloce system autosampler. The plate changing system holds up to 50 recommended SBS standard 384- or 96-well microplates.

Nanostream
626.351.8200
www.nanostream.com

Qiagen BioSprint DNA Plant Kits

Designed for fast and economical automated purification of plant genomic DNA, the new BioSprint DNA Plant Kits enable rapid and cost-effective automated purification of high-quality plant DNA using BioSprint workstations. The automated procedure completely removes all contaminants and enzyme inhibitors, and purified DNA is suitable for use in demanding downstream applications, such as PCR and real-time PCR, genotyping, and microsatellite analysis.

Qiagen
800.426.8157
www.qiagen.com

 

SNPs AND GENOTYPING

Biotage PyroMark ID

PyroMark ID is a pyrosequencing-based system for sequence-based microbial identification and resistance typing. The product is designed to provide real-time sequencing to clinical microbiologists for high-throughput identification of clinically important bacteria, fungi, and viruses. In addition, PyroMark ID analyzes SNPs responsible for antifungal, antiviral, and antibiotic resistance.

Biotage
www.biotagebio.com
+46 18 565942

To tell GT about new recently released products, e-mail John MacNeil, Senior Editor, at [email protected]

 

The Scan

Possibly as Transmissible

Officials in the UK say the B.1.617.2 variant of SARS-CoV-2 may be as transmitted as easily as the B.1.1.7 variant that was identified in the UK, New Scientist reports.

Gene Therapy for SCID 'Encouraging'

The Associated Press reports that a gene therapy appears to be effective in treating severe combined immunodeficiency syndrome.

To Watch the Variants

Scientists told US lawmakers that SARS-CoV-2 variants need to be better monitored, the New York Times reports.

Nature Papers Present Nautilus Genome, Tool to Analyze Single-Cell Data, More

In Nature this week: nautilus genome gives peek into its evolution, computational tool to analyze single-cell ATAC-seq data, and more.