New Algorithmic Method Helps Elucidate Molecular Causes of Inherited Genetic Diseases | GenomeWeb

Researchers at the Buck Institute for Age Research have developed a bioinformatics-based method to predict the molecular causes behind inherited genetic diseases. Using a combination of specially designed algorithms, the investigators interrogated available databases listing known sites of protein function to find other possible protein function sites. They then used the algorithms to look at proteins that are associated with disease--causing mutations and searched for statistical co-occurrences of mutations that were close to those functional sites.

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