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National Institutes of Health Issues Request For Applications for Proteomics Research

NEW YORK, Aug. 20 (GenomeWeb News) -The US National Institutes of Health issued an RFA last week to develop novel, broadly applicable proteomics technologies, including instrumentation, biophysical methods, reagents and infrastructure technologies. The RFA is entitled National Technology Centers for Networks and Pathways.

The technologies should be specifically directed at acquiring quantitative subcellular information and biologically relevant timescales necessary for temporal and spatial characterization of complex biochemical pathways and molecular interactions. The methods should not only catalogue proteins and their binary interactions - they should go on to quantitatively define the dynamics of complex systems.

"Proteomics experiments have consistently been characterized as falling into two broad classes, either directed at defining the physical interactions of proteins, or concerned with characterizing changes in the expression of proteins corresponding to internal or external perturbations of cells or systems," the RFA stated. "We feel it is necessary to begin a concentrated effort to develop and integrate a series of technologies orthogonal to these fundamental tools. These additional technologies should address the problems of temporal and spatial dynamics of protein function and interaction, and they should do so quantitatively.

"The maximum amount of funds that can be re quested through the RFA is $2 million per year, the NIH stated. Applicants who request $500,000 or more in direct costs per year must include a data-sharing plan in their application.

The deadline for RFA letters of intent is Jan 18, 2005, and the deadline for applications is Feb. 22, 2005.

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