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The Mysteries of TGF-Beta


In breast cancer, the TGF-beta signaling pathway can act as both a tumor suppressor and a tumor promoter, and a new study in the journal Oncogene details how and when, reports Garth Sundem at Science2.0. "Basically, a tumor hijacks an embryonic program and turns it back on," senior author Heide Ford tells Sundem. As embryos grow, they rely on a transcription factor called SIX1 to proliferate their cells quickly, and turn off SIX1 as adults. But the new study shows that some breast cancers turn SIX1 back on, turning TGF-beta from a tumor suppressor to a tumor promoter, Sundem says. "In this case, SIX1's microRNAs attach to and mute the section of TGF-beta that stops cell growth," he adds. "With TGF-beta silenced, the signal does nothing to stop cell growth, and instead encourages these cells to migrate into new tissues. Turning on SIX1 and its associated microRNAs is like removing the speed governor from a reckless teenager's Mustang convertible."

Ford says this means a high level of SIX1 expression is a signal that a breast tumor is using TGF-beta to proliferate, and those patients could then take TGF-beta inhibitors as part of their treatment.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.