MSI Scientists Measure Dose-Response Alignment Mechanism in Yeast | GenomeWeb

In a recent study out of the Molecular Sciences Institute, researchers led by Richard Yu have found that cell signaling systems can be described in a quantitative way, just like electrical circuits. In work recently published in Nature, Yu used genetic reporters — mostly fluorescently tagged proteins — to find that the mitogen-activated -protein kinase Fus3 provides negative feedback to the S. cerevisiae pheromone response pathway. It does that by adjusting the dose-response alignment to match receptor-ligand binding to downstream output.

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