In Nat Goodman’s review of the available approaches to high-performance sequence analysis (“Catch a Rising Star,” Oct. ’02) he notes that we at Aneda “march to a different drummer” and, having tried our product MPSRCH, he wonders how we achieve our “incredible speed” considering that we deliver the full Smith-Waterman. I couldn’t let Nat’s question go unanswered, so let me outline our approach, share a few of our secrets, and show you just how good the performance of the algorithm can be.

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In Science this week: International Wheat Genome Sequencing Consortium publishes the bread wheat cultivar Chinese Spring reference genome, and more.

At his FDA Law Blog, Jeffrey Gibbs discusses FDA's technical assistance for the draft Diagnostic Accuracy and Innovation Act.

The New York Times reports that genetic testing has uncovered unfaithful penguins at a Utah aquarium.

Cancer researcher loses funding under new Wellcome Trust anti-bullying policies, the Guardian reports.