Skip to main content

Most Prevalent Tick-Borne Cattle Pathogen Sequenced

NEW YORK, Dec.23 (GenomeWeb News) - Researchers have sequenced the genome of Anaplasma marginale, the most prevalent tick-borne pathogen of cattle.


The rickettsia-type bacterium causes disease and often death in cattle worldwide and persists lifelong in infected animals who recover, serving as a reservoir for infection of other animals. A. marginale, which has a 1.2-megabase genome, is difficult to culture because its lives inside of its host cell.


The researchers, from WashingtonStateUniversityand the US Department of Agriculture and Agricultural Research Service, sequenced the St. Maries strain of the pathogen and published their analysis in this week's online edition of PNAS. They found 949 annotated coding sequences in the genome, of which 62 are predicted to be outer membrane proteins. The genome also contains unusual functional pseudogenes that play a role in surface coat antigenic variation.

The Scan

US Supports Patent Waivers

NPR reports that the Biden Administration has announced its support for waiving intellectual property protections for SARS-CoV-2 vaccines.

Vaccines Versus Variants

Two studies find the Pfizer-BioNTech SARS-CoV-2 vaccine to be effective against viral variants, and Moderna reports on booster shots to combat variants.

CRISPR for What Ails You

The Wall Street Journal writes that CRISPR-based therapies could someday be used to treat common conditions like heart attacks.

Nature Papers Review Integration of Single-Cell Assay Data, Present Approach to Detect Rare Variants

In Nature this week: review of ways to integrate data from single-cell assays, and more.