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More Than One


A new diagnostic test called SNaPshot could allow oncologists test their patients for a wide range of mutations in more than one gene at the same time, reports the Guardian's Nic Fleming. This could lead to more personalized treatments as doctors could tailor combination treatments to target all or most of the mutations at once, instead of once at a time, Fleming says. "SNaPshot has been used to identify mutations at more than 50 sites in 14 key genes in patients with non-small-cell lung cancer, and is now being offered to patients with a range of other cancers," he adds. "This is thought to be the first time such a wide-ranging test has been used clinically." The test's developers, who published their study recently in Annals of Oncology, used a multiplex PCR approach to develop the diagnostic.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

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Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

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