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Money Rollin’ In

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Money Rollin’ In


Lion Bioscience could receive up to $11 million in a six-year licensing deal signed with Schering for its DiscoveryCenter software. The deal includes an up-front fee of about $3 million to $5 million, as well as an estimated $100,000 to $1 million in professional services and consulting fees per year. Schering, however, has the option to cancel the agreement after three years.


Find “New Schering Deal Could Net Lion Up to $11 Million” by searching: Schering


RNAi Rising


Layoffs? Downturn? What are you talking about? At the RNAi 2003 conference in Waltham, Mass., it might as well be 1999. Nearly 200 people have shown up for this one-track, two-day event off I-95, which was organized not by a major conference company but by a former PerkinElmer scientist, Krishnarao Appasani. The talks veered toward a consensus that there is real promise that this technology will deliver.


Find “RNAi Draws a Crowd to Waltham: Optimism Abounds” by searching: Waltham Weekly


DIY Pays Off


“It was not just a fortuitous coincidence that we happened to have an array that could do this. We’ve been planning for this.”

— Joe DeRisi, University of California, San Francisco, describing how his lab used its homebrew microarray to detect coronavirus in SARS patient samples from the CDC


Find “UCSF’s Joe DeRisi on Microarrays in the Hunt for the SARS Virus” by searching: DeRisi Weekly


Look at the Big Picture


“Our job as CEOs is to step in and paint a picture for the client of what we can achieve for them, and then get them to pay for the vision. If they’re paying for the technology, we’re going to go out of business.”

— Richard Gill, AnVil CEO


Find “Executive Roundtable: Is Clinical Genomics the Cure for ‘Not Invented Here’ Syndrome?” by searching: Gill Weekly


Stars of SARS


As researchers drew worldwide attention for draft sequences of the severe acute respiratory syndrome coronavirus genome, proteomics researchers were quietly working their end of the SARS problem. John Wilkins, Kenneth Standing, and their colleagues sequenced two of the coronavirus proteins by mass spectrometry. One appears to be recognized by the immune system and could potentially become the starting point for a vaccine.


Find “University of Manitoba Proteomics Researchers Tackle SARS Virus Proteins” by searching: SARS Weekly


Us, Paranoid? Puh-leez


Will the pharmaceutical industry respond to overtures by Janet Woodcock, director of the FDA’s Center for Drug Evaluation and Research, to put their squabble-laced history behind them and infuse some ‘trust’ into both parties’ pharmacogenomics initiative? Some say pharma must first put its “paranoia” behind it.


Find “Trying to Rally PGx, CDER’s Woodcock Solicits ‘Trust’ Between Pharma, FDA” by searching: CDER


The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.