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Money in Massachusetts


With $2.1 billion in NIH grant funding, Massachusetts receives more money from the health institutes than any other state save California. A sizable portion of that finances integrated biology research — one chunk of nearly $60 million goes to Eric Lander at the Broad Institute. For this chart, GT culled through the grants to find ones clearly related to the disciplines under the systems biology umbrella, and for the sake of space, selected the institutes with the most funding. This list, current as of December, is not comprehensive.


Amount PI Grant Title

Agencourt Bioscience

$10,000,000 Douglas Smith Agencourt Sequencing Center

$1,375,800 Gina Costa Bead-based Polony Sequencing

Boston University

$2,703,183 Lindsay Farrer Genetic Epidemiological Studies of Alzheimer Disease

$2,301,213 David Atkinson Structural Cell Biology in Cardiovascular Disease

$1,975,093 Haralambos Gavras Identifying Genes in Abnormal Blood Pressure

$787,077 Julie Palmer Gene Polymorphisms in Relation to Cancer in Black Women

Brigham & Women’s Hospital

$3,925,000 Isaac Kohane Informatics for Integrating Biology and the Bedside

$1,522,301 Cynthia Morton DGAP: Developmental Genome Anatomy Project

$1,258,500 Claude Lechene National Resources for Imaging Mass Spectrometry

$1,255,374 Raju Kucherlapati Mouse Models for DNA Repair Defects

$1,044,994 David Beier Genetic Analysis of Developmental Mutations

$972,842 Daniel Cramer Proteomic/Epidemiologic Paths to Ovarian Cancer Screening

CBR Institute for Biomedical Research

$2,467,065 Judy Lieberman RNA Interference as a Weapon Against Bioterrorism

Children’s Hospital, Boston

$1,464,230 Louis Kunkel Gene Expression in Normal and Diseased Muscle Development

$774,429 Scott Pomeroy Genomic Analysis of Medulloblastomas

$712,771 Leonard Zon Characterizing the Zebrafish Genome

Dana-Farber Cancer Institute

$1,875,042 Ronald Depinho Genetics and Biology of Malignant Glioma

$787,887 Robert Gentleman A Statistical Computing Framework for Genomic Data

$692,730 Marc Vidal Integrated Interactome Mapping

$664,478 Thomas Roberts Genomic-wide Kinase Sequencing of Pediatric Brain Tumors

Harvard University

$4,500,000 William Gelbart FLYBASE: A Drosophila Genomic and Genetic Database

$1,998,270 George Church Molecular and Genomic Imaging Center

$1,175,214 Gerhard Wagner NMR and Computational Studies of Biomolecules

$1,072,854 Gerhard Wagner Integrated and Sensitive Metabolomics Platform/Human Disease

$963,534 Jonathan Seidman Genomics of Cardiovascular Development

$893,112 Norbert Perrimon Functional Genomic Screen Using RNAi in Drosophila

$806,932 Joshua LaBaer Functional Proteomics of Breast Cancer

$642,513 David Reich A Whole Genome Admixture Scan for Multiple Sclerosis

Joslin Diabetes Center

$3,500,001 Ronald Kahn Diabetes Genome Anatomy Project

Massachusetts General Hospital

$3,821,536 Bruce Rosen Morphometry Biomedical Informatics Research Network

$1,901,602 Patricia Donahoe Comparative Genomics to Correct Human Lung Hypoplasia

$735,250 Mason Freeman Genomic Analysis of Stress and Inflammation


$57,976,493 Eric Lander Large Scale Sequencing and Analysis of Genomes

$3,374,550 Stacey Gabriel An NCRR Center for High-Throughput SNP Genotyping and Analysis

$1,037,042 Isaac Kohane Training Grant in Bioinformatics and Functional Genomics

$984,732 Robert Griffin Solid State NMR Studies of Membrane Proteins

$809,333 Mark Daly The Haplotype Map of the Laboratory Mouse Genome

Whitehead Institute

$1,541,799 Daniel Ehrlich High-Throughput BioMEMS DNA Sequencing

$1,054,154 Rudolf Jaenisch Genomic Imprinting and the Cloning of Mice

$899,401 Rudolf Jaenisch DNA Methylation, Gene Regulation, and Cancer

$879,814 David Page Genomic Studies of Sex Chromosomes

$868,180 Richard Young Genomic Regulatory Networks in Innate Immune Cells


The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.