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Molecular Staging Technology Can Do On-Chip Protein-Signal Amplification

NEW YORK, April 18 - An article in Nature Biotechnology this month demostrates a new protein microarray application for Molecular Staging's amplification technology.


The paper shows how the company's isothermal Rolling Circle Amplification technology can be used for on-chip protein-signal amplification.


The authors descibe a functional antibody chip that can detect 75 differnet low-abundance human cytokines, and another 51-feature dendritic cell cytokine chip.


The success of this technology shows that multiplexed protein analysis can be both technically and economically feasible, the authors claim. "RCA-amplified protein arrays allowed, for the first time, [greater than] 50 members of a family of proteins to be measured simultaneously without compromise of biologically relevant sensitivity."


Molecular Staging, of New Haven, Conn., sees RCAT as a potential replacement for PCR. Potential applications include point-mutation detection and infectious-agent diagnosis through direct detection of viral DNA or RNA.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.