MicroRNA Family Link in Tumor-Suppressor Network | GenomeWeb

Two groups of researchers separately published data showing that the p53 tumor-suppressor gene directly targets members of the evolutionarily conserved miR-34 family of microRNAs, which is known to suppress cell proliferation.

The findings, which appeared in the online editions of Nature and Molecular Cell, suggest that this small non-coding RNA family may be a key component in the p53 tumor-suppressor network, which controls cellular responses to signals such as DNA damage and oncogene activation.

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