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Microchip Biotechnologies Teams with Stanford to Accelerate Pyrosequencing

NEW YORK (GenomeWeb News) – Microchip Biotechnologies is working with scientists at Stanford University to develop a front-end microfluidic-based sample preparation system aimed at streamlining and speeding up pyrosequencing projects, the company said today.
Steven Jovanovich, CEO of Dublin, Calif.-based MBI, said the goal of the work is to automate the complex upstream template production process by using the firm’s Microscale-On-chip Valves to “greatly reduce upfront sample preparation time,” and to cut labor and reagent costs.
The privately held company is working with Stanford scientist Mostafa Ronaghi, who the company said was involved in introducing pyrosequencing in Sweden in the 1990s.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.