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Microarrays Used to Predict Chemotherapy Response in Breast Cancer, Lancet Study Reports

NEW YORK, Aug. 1 - A preliminary study published in the Aug. 2 issue of The Lancet reported that a gene expression profiling technique using microarrays could predict which breast cancer sufferers would respond to chemotherapy.


The study, which was partially funded by Aventis, was conducted over two years and involved 24 women receiving docetaxel, a common breast cancer chemotherapy drug. Scientists used arrays to find 92 genes that correlated with docetaxel response. This group of genes positively predicted drug response 92 percent of the time.


This was the first study to successfully predict chemotherapy response in breast cancer using this technique, according to Jeff Boyd, director of the Gynecology and Breast Cancer Research Laboratory at MemorialSloan-KetteringCancerCenter.


The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.