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Methods for Proteomics Research, Claire Fraser-Liggett, Young Investigators Then and Now, and More

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In December 2001, Genome Technology's cover story focused on proteomics' dependence on two-dimensional gels, even after Ruedi Aebersold had developed his Isotope-Coded Affinity Tag strategy while at the University of Washington. Aebersold is now at the Swiss Federal Institute of Technology, and in July, he and his colleagues published a paper in Molecular Systems Biology in which they reported using a directed mass spectrometry strategy to detect peptides from a pathogen at different states.

Claire Fraser made an appearance on the cover of GT's January 2002 issue, and talked about the goings-on at the Institute for Genomic Research, which she co-founded in 1992 with her then-husband Craig Venter. In 2002, TIGR was running about 40 ABI 3700s and sequencing was $2 per reaction, Fraser said, with an average of 15,000 reactions per megabase. TIGR is now part of the J. Craig Venter Institute, and Fraser, now Claire Fraser-Liggett, is at the University of Maryland where she directs the school's Institute for Genome Sciences.

Five years ago, GT began featuring profiles of young investigators. Among the inaugural class were Massachusetts General Hospital's Bradley Bernstein and MIT's Manolis Kellis. Bernstein said that his main interest was in how epigenetic changes affect cell identity and cell lineage, and he was recently named an HHMI Early Career Scientist. Kellis said his goal was to understand how evolution worked using model organisms and computational biology. This issue of GT covers a new Nature paper from Kellis that compared more than two dozen mammalian genomes to build a map of evolutionary constraint.

Last year, GT continued that profile series, and spoke with Washington University in St. Louis' Makedonka Mitreva and Michael Schatz at Cold Spring Harbor Laboratory, among others. Since then Mitreva published a Nature Genetics paper on the genome of Trichinella spiralis, and Schatz was part of the team that introduced the open-source software package Quake.

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Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

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