Skip to main content

Metaphorics, Syrrx Ink Ligand-Docking Partnership

NEW YORK, March 1 - Bioinformatics company Metaphorics has struck a  research collaboration with drug-discovery firm Syrrx designed to improve computational tools for docking ligand molecule structures into protein binding sites.

The companies said on Thursday that the collaboration seeks to create new software that might help scientists better predict "the potential complementarity" between ligands and proteins.

Metaphorics, of Mission Viejo, Calif., will bring its DockIt distance-geometry-based technology to the table. This technology was designed to automate high-throughput docking of small molecules versus macromolecular targets.

 

In exchange, Syrrx, which has used DockIt in its own research for one year, will provide its experience in compiling and analyzing structural-proteomics data. Syrrx, based in San Diego, said its DockIt software runs on a Linux cluster of nearly 500 nodes, which it said will increase to 1,000 nodes by mid-year.

According to a statement, Metaphorics and Syrrx believe that "the problem of assessing complementarity between ligands and macromolecular targets is a key area for improvements in existing docking methods."

 

Financial details of the deal were not disclosed.

 

"As one of the leaders in the structural proteomics field, Syrrx is in an excellent position to identify necessary advancements in bioinformatics tools," said Scott Dixon, Metaphorics' Chief Technology Officer. "They have built one of the most advanced technology platforms for the determination of protein structures and this makes them an ideal collaborator for the further development of DockIt."

The Scan

Possibly as Transmissible

Officials in the UK say the B.1.617.2 variant of SARS-CoV-2 may be as transmitted as easily as the B.1.1.7 variant that was identified in the UK, New Scientist reports.

Gene Therapy for SCID 'Encouraging'

The Associated Press reports that a gene therapy appears to be effective in treating severe combined immunodeficiency syndrome.

To Watch the Variants

Scientists told US lawmakers that SARS-CoV-2 variants need to be better monitored, the New York Times reports.

Nature Papers Present Nautilus Genome, Tool to Analyze Single-Cell Data, More

In Nature this week: nautilus genome gives peek into its evolution, computational tool to analyze single-cell ATAC-seq data, and more.