Skip to main content
Premium Trial:

Request an Annual Quote

Merck Taps Dana-Farber for Genomic Analysis of Cancer Therapeutics

NEW YORK (GenomeWeb News) – The Dana-Farber Cancer Institute will use cross-species genomic analysis and validation testing in a cancer drug collaboration with Merck, the Institute said today.
 
Under the agreement, Merck will provide the Center for Applied Cancer Science at Dana-Farber with up-front and research support funding and with milestone and royalty payments if a drug is approved for marketing. CACS will retain the right to develop its antibodies independently from the collaboration with Merck.
 
The CACS will work with Merck to develop assays for lead compound discovery, and then test the drugs in its model systems that “closely replicate human disease,” CACS said.
 
CACS faculty will work with Merck to further evaluate tumor pathobiology and clinical outcomes to better pinpoint the tumor types that are most susceptible to drug candidates.
 
Further terms of the alliance were not disclosed.

The Scan

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.

US Survey Data Suggests Ancestry Testing Leads Way in Awareness, Use of Genetic Testing Awareness

Although roughly three-quarters of surveyed individuals in a Genetics in Medicine study reported awareness of genetic testing, use of such tests was lower and varied with income, ancestry, and disease history.

Coral Genome Leads to Alternative Amino Acid Pathway Found in Other Non-Model Animals

An alternative cysteine biosynthesis pathway unearthed in the Acropora loripes genome subsequently turned up in sequences from non-mammalian, -nematode, or -arthropod animals, researchers report in Science Advances.

Mosquitos Genetically Modified to Prevent Malaria Spread

A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances.