Skip to main content
Premium Trial:

Request an Annual Quote

Melanoma Exome Exposed

Premium

In what they're calling the "most comprehensive view of melanoma's genetic landscape," researchers at the National Human Genome Research Institute and elsewhere say they have sequenced several metastatic melanoma exomes, according to an agency press release. The researchers say they've made "surprising" new discoveries which they detail in a study published in Nature Genetics. Among the discoveries, the team identified 68 genetic changes that appear to be somatically mutated at elevated frequency, and found 16 genes which they deemed to be melanoma driver mutations — of the 16, only BRAF had previously been implicated in melanoma, NIH's press release says. "The ionotropic glutamate receptor gene, GRIN2A, was the most highly mutated of the genes newly implicated in melanoma. It contained mutations in 33 percent of an NCI sample set and in 25 percent of a larger set of samples that combined those maintained by NCI and two other collections. The researchers suggest that this gene is important because of its role in the signaling pathway," NIH adds. The researchers also suggest that the TRRAP gene is also a driver of melanoma and likely an oncogene, one of the study's most important findings.

The Scan

Dropped Charges

The US Justice Department has dropped visa fraud charges against five Chinese researchers, according to the Wall Street Journal.

More Kids

The Associated Press says Moderna is expanding its SARS-CoV-2 vaccine study to included additional children and may include even younger children.

PNAS Papers on Rat Clues to Human Migration, Thyroid Cancer, PolyG-DS

In PNAS this week: ancient rat genome analysis gives hints to human migrations, WDR77 gene mutations in thyroid cancer, and more.

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.