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Measles, Mumps, Multiple Myeloma

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While most cancer vaccines are intended to fight cancers that have already developed, Massachusetts-based biotech start-up OncoPep is working on a vaccine designed to prevent multiple myeloma before it even starts, says Technology Review's Courtney Humphries. The vaccine is meant for patients who have precursors of the blood cancer in their cells — it contains a combination of peptides that are specific to multiple myeloma in order to "train the immune system to recognize and attack cancer cells bearing these peptides," Humphries says. The company hopes that detecting the cancer in the early stages could lead to effective early intervention, and that vaccines like this one could help patients while their own immune systems are still healthy.

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.