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Mayo Clinic Research Team Models SARS Enzyme; Identifies Potential SARS Drug Targets

NEW YORK, Aug. 20 (GenomeWeb News) - After simulating the three-dimensional structure of a SARS enzyme responsible for the replication of the deadly virus, a Mayo Clinic research team has identified via computer twenty molecules that could potentially interact with the enzyme to thwart its function.


The 3-D structure of the functionally important SARS enzyme was published last week in the online version of the journal Proteins: Structure, Function and Bioinformatics, after Yuan-Ping Pang and his research group solved the structure using x-ray crystallography techniques and computer modeling.  


Pang used a Mayo Clinic in-house chemical database to search for molecules that could potentially interact with the SARS enzyme. The computer structures of the 20 chemicals he identified were sent to the Southern Research Institute in Birmingham, Ala.for further testing to see if they could work as anti-SARS drugs.

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