Mass Spec Missive

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The generally fine article on mass spectrometry in the June issue of Genome Technology (“A Spectrum of Choices,” p. 50) had several technically incorrect statements that I’d like to bring to your attention.

First, the author confuses the ionization of proteins vs. peptides in the article. Most proteomics studies done via mass spec involve the digestion of proteins into peptides, followed by the mass analysis of the peptides produced by the protein digest.

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