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Maryland s Grant Windfall

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With a major biotech beltway running through the state, it’s no surprise that Maryland raked in nearly $1.5 billion in NIH grant funding for researchers this year. This state is home to TIGR, several universities, and a number of organizations that do contract work for Bethesda-based NIH.

To compile this chart, GT sorted through NIH’s grants-by-state database to find ones clearly related to the disciplines under the systems biology umbrella, and for the sake of space, selected those with the most funding. This list, current as of late June, is not comprehensive.

AWARD

PI PROJECT TITLE
J. Craig Venter Institute    

$1,032,312

Samuel Levy NHLBI DNA Resequencing and Genotyping Program Lab Center
Johns Hopkins University    

$8,169,000

David Valle Genotyping for Locating Human Disease Genes
$3,000,000 David Sidransky Integrated Development of Novel Molecular Markers

$2,664,689

Lewis Becker Genotypic Determinants of Aspirin Response in High-Risk
$2,262,200 Jef Boeke Yeast Genetic Interaction Map
$1,100,000 Andrew Feinberg Center for the Epigenetics of Common Human Disease

$1,000,000

Aravinda Chakravarti

Human Genomic Polymorphism in Autism

$930,585 Kathy Helzlsouer Clue Studies—Evaluating Biomarkers of Carcinogenesis
$915,959 Ann Pulver A Genome-Wide SNP Association Study: Schizophrenia

$827,244

Alan Scott SNP Discovery and Analysis in Craniofacial Birth Defects
$811,890 Gordon Tomaselli Expression Profiling in Canine Models of Human Disease
$797,391 Alan Scott NHLBI DNA Resequencing and Genotyping Program Lab Center
$715,394 Paul Englund Structure and Synthesis of DNA

$639,615

David Thomas

Hepatitis C Pathogenesis and the Human Genome

$628,589 Aravinda Chakravarti Genetic Epidemiology of Hypertension: Genomic Cores
$575,000 Steven Brant IBD Gene Mapping by Clinical and Population Subsets

$562,312

Stephen Baylin DNA Methyltransferase Gene Expression in Colon Cancer
$542,627 Peter Devreotes G-Protein Linked Signaling Pathways in Chemotaxis
$526,961 Daniel Lane Hormonal Control of Adipose Gene Expression
$518,007 Donald Zack Regulation of Rhodopsin Gene Expression

Kennedy Krieger Research Institute

   
$1,822,528 Kirby Smith Genetic Causes of Mental Retardation
Large Scale Biology    

$451,178

Sandra Steiner National Center for Toxicogenomics Resources — Proteomic Analysis/Identification
Medstar Research Institute    

$652,865

Barbara Howard Genetics of Coronary Artery Disease in Alaskan Natives
Northrop Grumman Information Technology    

$6,909,999

Richard Scheuermann Bioinformatics Resource Centers for Biodefense
The Institute for Genomic Research    

$23,909,000

Scott Peterson Pathogen Functional Genomics Resource Center
$11,303,969 Claire Fraser Microbial Genome Centers
$10,000,000 Karin Remington TIGR/JTC Large-Scale Sequencing Production Center

$3,619,904

Owen White Bioinformatics Resource Centers for Biodefense
$1,391,005 Jonathan Eisen Tetrahymena Genome Sequencing Project
$671,976 Steven Salzberg Computational Gene Modeling and Genome Sequence Assembly

$635,554

Steven Gill Comparative Genomics of the Chlamydiaceae
$592,593 Steven Gill Community Genomics of the Human Oral Microbiome
$541,041 John Quackenbush A Comprehensive System for Microarray Data Analysis

$500,000

Karin Remington TIGR/JTC Large-Scale Sequencing Production Center
$446,178 William Nierman Regulation of Burkholderia mallei virulence genes
University of Maryland    

$2,897,961

Alan Shuldiner Genome-wide Search for CVD Gene-Environment Interactions
$769,423 Alan Shuldiner Longevity Genes in Founder Populations
$662,837 Steven Kittner Genetics of Early Onset Stroke
$624,949 John Warren Genetics of Interstitial Cystitis

$624,049

Alan Shuldiner Genetics of Diabetes in the Amish

University of Maryland Biotechnology Institute

   

$1,484,870

John Moult From Genomic Sequences to Protein Structure and Function

 

The Scan

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.

Lupus Heterogeneity Highlighted With Single-Cell Transcriptomes

Using single-cell RNA sequencing, researchers in Nature Communications tracked down immune and non-immune cell differences between discoid lupus erythematosus and systemic lupus erythematosus.

Rare Disease Clues Gleaned From Mobile Element Insertions in Exome Sequences

With an approach called MELT, researchers in the European Journal of Human Genetics uncovered mobile element insertions in exomes from 3,232 individuals with or without developmental or neurological abnormalities.

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.