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Markers/Short Reads: Sep 1, 2003


RNAi therapeutics firm Benitec has kept a low profile since its founding in 1997. But in June the Brisbane, Aust.-based company was awarded patents in the US and UK covering the use of DNA-directed RNAi that Benitec says will reshape the current landscape of RNAi IP.


The Prolinx staff isn’t answering the phone anymore. The Bothell, Wash., company, founded in 1995 with proteomics and array technology, has filed for bankruptcy. The last news release issued by the company came out in October 2002 and announced a restructuring that was hoped would help Prolinx focus on delivering a product.


Caliper Technologies, which recently acquired Zymark, laid off 50 employees, or less than 10 percent of its combined workforce. The reduction will help the company save $10 million annually, according to Caliper.


In better news, Lucigen won a $750,000 SBIR grant from DOE to commercialize its gene mining technology, funded through the Genomes to Life program.


Sloning BioTechnology won €1,144,000 in grants from the Bavarian state and German government to develop its technology for gene synthesis. Based near Munich, the three-year-old company has 18 employees.

ParAllele BioScience and Baylor College of Medicine formed a collaboration to examine the genetic basis of certain congenital heart irregularities that affect children and possibly the elderly as well.


Abbott Laboratories and Dharmacon teamed up to develop an siRNA library covering 4,000 genes to select drug targets. Dharmacon also announced that Stephen Scaringe, former CEO, is now CSO of the company.


Eli Lilly signed a three-year lease for 10,000 square feet of research space for structural genomics studies. The project will be done in conjunction with Structural Genomix, with whom Lilly signed a research agreement earlier this year.


The University of Buffalo Center of Excellence in Bioinformatics scored $2.4 million in federal aid for 2004. Ultimately, the center is looking to take in another $12 million to wrap up the $25 million in federal funding it originally requested.


Nonlinear Dynamics said it did not renew an OEM agreement with the proteomics group at Amersham Biosciences, which has used Nonlinear’s software in its products since 1996. Nonlinear CEO Will Dracup attributed the decision to a divergence between the companies’ proteomics efforts.

Rubicon Genomics announced a deal with the Sanger Institute for DNA amplification in studies of diabetes and obesity. The research will look at 5,000 subjects.


PPD closed its Menlo Park, Calif., functional genomics facility as part of a restructuring. The company will also consolidate its discovery research, currently distributed between centers in North Carolina and Wisconsin. PPD partner SurroMed, which plans to move into the Menlo Park space, will study some of PPD’s cancer biomarkers.


This month, federal programs looking to give away money have hit the road. In an eight-day, six-state bus tour, representatives from various agencies including NIH, NSF, DOD, and NIST will make themselves available to meet with people looking to capture their chunk of the $1.6 billion being offered by the agencies. Details on the mid-September tour, which hits primarily western states, can be found at


An Indiana University research team led by evolutionary geneticist and biology professor Michael Lynch was awarded a $5 million, five-year NSF grant to study the causes of genetic recombination.


TurboWorx packed up its New Haven, Conn., digs and moved to Burlington, Mass., to accommodate more growth in the company.


The Scan

Driving Malaria-Carrying Mosquitoes Down

Researchers from the UK and Italy have tested a gene drive for mosquitoes to limit the spread of malaria, NPR reports.

Office Space to Lab Space

The New York Times writes that some empty office spaces are transforming into lab spaces.

Prion Pause to Investigate

Science reports that a moratorium on prion research has been imposed at French public research institutions.

Genome Research Papers on Gut Microbe Antibiotic Response, Single-Cell RNA-Seq Clues to Metabolism, More

In Genome Research this week: gut microbial response to antibiotic treatment, approach to gauge metabolic features from single-cell RNA sequencing, and more.