Long a proponent of taking a top-down approach to systems biology — that is, starting with disease phenotype and clinical data and working back toward an understanding of the disease on a molecular and genomic level — Michael Liebman’s latest move is a chance to prove his approach is as good in action as it is in theory.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.