Skip to main content
Premium Trial:

Request an Annual Quote

Lexicon Genetics to Scale Up Functional Genomics Efforts

NEW YORK, April 19 - Lexicon Genetics unveiled a new plan Thursday to determine the in vivo function of 1,000 genes per year for the next five years.

The company plans to find the functions of 5,000 genes, approximately the number of drug targets many scientists believe are encoded in the human genome by 2006, Arthur Sands, Lexicon's CEO, said in a statement.

"Lexicon is amassing the world's largest gene knockout infrastructure, and today we are revealing the magnitude of our capabilities," Sands said.

Lexicon plans to use its knockout gene targeting technology, which generates mice with alterations in specific genes, to determine the function of the 2,500 genes over five years. Lexicon's OmniBank library, which contains clones for about 40 percent of the mammalian genome, will identify the other 2,500 genes, Lexicon said.

To accommodate the company's research efforts, Lexicon, based in The Woodlands, Texas, is adding an additional 300,000 square feet to its physical plant, an addition expected to be complete by the end of the year.  
The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.