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Lexicon Genetics Gets Seventh Gene Targeting Patent

NEW YORK, Dec. 3 (GenomeWeb News) - Lexicon Genetics said today it was issued a patent for its gene targeting knockout mouse technology, US Patent No. 6,653, 113.

The patent, issued Nov. 25,   is entitled "High efficiency gene targeting in mouse embryonic stem cells."   It provides methods for changing the genome of an animal cell through construction of a "targeting" DNA molecule with the desired mutations, then introducing this targeting DNA into a cell in order to induce homologous recombination of the cell's genome. Cells in which this modification has been successfully introduced are then selected.


The Woodlands, Texas-based company said this patent is the seventh it holds in the area of gene targeting.


The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.