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Lexicon Genetics Finds New Oncogene

NEW YORK, April 23-Lexicon Genetics said today that it has discovered and validated a previously undescribed oncogene.


The gene, which produces a kinase enzyme, seems to be involved in solid tumor cancers. Overexpression of the gene in mice caused tumor formation, and blocking the enzyme target decreased cell growth and proliferation.


Lexicon intends to identify compounds to inhibit the enzyme target within a year.


Kinases are of interest in oncology research because of their role in intracellular signaling, and the promise that they may provide a key to nontoxic cancer drugs.


Lexicon Genetics, based in The Woodlands, Texas, is publicly owned. The company uses knockout technology to discover gene function.

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