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Legionnaires Disease Bacterium Genome Offers New Insights

NEW YORK, Sept. 24 (GenomeWeb News) - Scientists led by ColumbiaUniversityhave sequenced the genome of Legionella pneumophila, the bacterium that causes Legionnaires' disease.

 

The analysis of the genome, which is four million base pairs long, was published in this week's Science. The ColumbiaGenomeCenterscientists found genes for unexpected metabolic pathways, new candidate virulence determinants, selective expansions of certain gene families, and a stretch of DNA that can exist in chromosomal and episomal forms.

 

L. pneumophila was first recognized as a human pathogen after  an outbreak of fatal pneumonia at an American Legion convention in Philadelphiain the 1970s. The bacterium, which is found within biofilms as well as fresh and industrial water systems, is able to survive in difficult environments, for example plumbing systems treated with potent biocides. In addition, it has the ability to steer the organelle trafficking systems of hosts cells.

The Scan

WHO Seeks Booster Pause

According to CNN, the World Health Organization is calling for a moratorium on administering SARS-CoV-2 vaccine boosters until more of the world has received initial doses.

For Those Long Legs

With its genome sequence and subsequent RNAi analyses, researchers have examined the genes that give long legs to daddy longlegs, New Scientist says.

September Plans

The New York Times reports that the US Food and Drug Administration is aiming for early September for full approval of the Pfizer-BioNTech SARS-CoV-2 vaccine.

Nucleic Acids Research Papers on Targeting DNA Damage Response, TSMiner, VarSAn

In Nucleic Acids Research this week: genetic changes affecting DNA damage response inhibitor response, "time-series miner" approach, and more.