Skip to main content
Premium Trial:

Request an Annual Quote

Kreatech Licenses Labeling System To Schleicher & Schuell for Protein Arrays

This article has been changed and clarified to more accurately describe the Universal Linkage System.

 

NEW YORK, Aug. 3 (GenomeWeb News) - Kreatech has sub-licensed its Universal Linkage System to Schleicher & Schuell for incorporation into Schleicher & Schuell's two-color labeling and fluorescent detection kit for its serum biomarker chip, the companies said today.

 

The Universal Linkage System includes the ULS molecule, which consists of a platinum complex, a detectable molecule, and a leaving group that is displaced when the target reacts with the molecule, Kreatech said. This molecule bings to the N7 position of guanine to form a label for DNA and RNA, and in proteins, binds to nitrogen and sulphur that contains side chains of methionine, cysteine, and histidine. The ULS can then be coupled to labels such as fluorochromes, biotin, dinitrophenol, and horse radish peroxidase.

 

With the serum biomarker chip, each sample is labeled with either biotin or fluorescein, and then the samples are pooled and exposed to the antibody microarray so they can competitively bind to the 120 different antibodies spotted on the chip. Bound labeled proteins are detected using a streptavidin dye conjugate or the anti-fluorescein dye conjugate.

 

The ULS labeling system, according to the companies, minimizes background fluorescence because it uses indirect fluorescence detection.

 

The companies did not disclose the financial terms of the agreement.

 

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.