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Judge a Cancer Cell by its Surface


A new study published in PNAS this week by researchers at Stanford University suggests that it may not be completely necessary to get inside a cancer cell to destroy it, reports the Los Angeles Times' Eryn Brown. CD47, a cancer cell-surface protein, keeps the immune system from destroying the cells, and the authors of this new study found that inhibiting CD47 in mice can slow tumor growth, Brown says. The team injected mice with CD47-binding antibodies, which blocked it from interfering with the immune system. "Antibody treatment inhibited the growth of almost all of the solid tumors and was able to wipe out some smaller cancers altogether," Brown says. "Even when it didn't destroy a large tumor … the antibody prevented the cancer from spreading and wiped out metastases scattered through the body." The method worked against ovarian, breast, bladder, liver, prostate, and brain cancer cells, she adds. A team of researchers plans to test the therapy in leukemia patients in Britain, and the Stanford team hopes to start trials on humans with solid tumors within two years.

The Scan

mRNA-Based Vaccine on the Way in China

China may soon have its own mRNA-based vaccine, according to Nature News.

Arranged Killing, Fraud Alleged by Prosecutors

The Wall Street Journal reports that prosecutors allege that the co-founder of a biotech arranged to have a business associate who threatened to expose him as a fraud killed.

Whirlwind Decade of CRISPR

The New York Times looks back at the 10 years since the University of California, Berkeley's Jennifer Doudna and her colleagues published their CRISPR paper.

PNAS Papers on Blue Cone Monochromacy Structural Variants, HIV-1 Mutant, T-ALL

In PNAS this week: structural variants linked to blue cone monochromacy, HIV-1 variants affecting the matrix protein p17, and more.