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Johns Hopkins to Evaluate Rosetta Genomics' Lung miRNA Cancer Diagnostic

NEW YORK (GenomeWeb News) - Rosetta Genomics said today that it is partnering with Johns Hopkins University School of Medicine on a clinical assessment study of its microRNA-based miRview Squamous diagnostic, which is designed to differentiate squamous from non-squamous non-small cell lung cancer.

The study will compare miRview squamous with available immunohistochemistry methods.

Rosetta said in a statement that the test is in the "final stages of development" and is expected to be commercially available by the end of 2008.

The company said that until recently differentiation between squamous and non-squamous non-small cell lung cancer “was not particularly relevant from a therapeutic or prognostic standpoint” because there were no therapies designed for a specific NSCLC sub-type.

However, Rosetta added, “a recently approved angiogenesis inhibitor for NSCLC has been shown to have severe side effects for squamous-cell lung cancer patients," which has led patients with squamous-cell histology "to be regarded by many as inappropriate candidates for therapy with this drug.”

In addition, the company said that “several other” targeted drugs for NSCLC currently under development “may require this type of accurate differentiation due to different side effect profiles or different levels of efficacy.”

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