I appreciate Nat Goodman’s articles addressing important current genomics research issues.
I’m referring first to his article (“Microarray Mining Made Easy … Almost,” Nov. ’00) questioning why microarray users didn’t feel the need to replicate. How did they determine if a gene was up- or down-regulated to a significant level as opposed to the null hypothesis that it didn’t change in expression? How was the notorious “x-fold” level determined?”
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