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IP Update: Recent Patents Awarded to Microsoft, Life Tech, and More

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Recent Patents of Interest in Proteomics

US Patent No. 8,538,706. Method for affinity scoring of peptide/protein complexes. Inventors: Johan Desmet; Geert Meersseman; Nathalie Boutonnet; Jurgen Pletinckx; Krista De Clercq; Ignace Lasters. Assignee: Lonza Biologics

Covers an invention for quantitative structure-based affinity scoring of peptide/protein complexes using a force field function applied to all-atom representations of peptide/receptor complexes.


US Patent No. 8,536,521. Mass spectrometry systems. Inventor: Robert Grothe. Assignee: Cedars-Sinai Medical Center

Covers methods of mass spectrometry including a phase-modeling analysis approach for identification of proteins and peptides.


US Patent No. 8,535,895. Highly sensitive system and method for analysis of troponin. Inventors: Philippe Goix; Robert Puskas; John Todd; Richard Livingston; Held; Allan Wu. Assignee: Singulex

Covers methods for the sensitive detection of cardiac troponin.


US Patent No. 8,535,894. Antibody complexes and methods for immunolabeling. Inventors: Robert Archer; Richard Haugland; Rosaria Haugland; Joseph Beechem; David Hagen. Assignee: Life Technologies

Covers labeling reagents and methods for labeling primary antibodies and detecting targets in a samples using complexes combining target-binding antibodies and one or more labeling reagents.


US Patent No. 8,535,891. Method of predicting acute appendicitis. Inventors: Alex Kentsis; Hanno Steen; Richard Bachur. Assignee: Children's Medical Center Corporation

Covers a protein biomarker test for predicting the likelihood of acute appendicitis. The biomarkers include: leucine-rich alpha-2-glycoprotein; calgranulin; alpha-1-acid glycoprotein 1; plasminogen; mannan-binding lectin serine protease 2; zinc-alpha-2-glycoprotein; Apolipoprotein D; and alpha-1-antichymotrypsin.


US Patent No. 8,532,348. Iterative processing. Inventors: Brandon Hunt; Ernst Henle. Assignee: Microsoft

Covers a method of identifying chromatographic or mass spectrometric peaks by redefining a bounding area in sets of such images, defining and localizing peaks that point to a common feature of interested and then locating other peaks associated with the feature of interest.


US Patent No. 8,530,408. Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrate. Inventors: Ilia Davydov; John Kenten; Hans Biebuyck; Pankaj Oberoi. Assignee: Meso Scale Technologies

Covers methods for detecting, measuring, and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates and modulators of N-end rule ubiquitylation.


US Patent No. 8,530,175. Methods for detecting pre-diabetes and diabetes using differential protein glycosylation. Inventors: Srinivasa Nagalla; Charles Roberts. Assignee: DiabetOmics.

Covers methods of identifying pre-diabetic patients at significant risk of developing diabetes by examining the glycosylation pattern of proteins.


US Patent No. 8,525,104. Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry. Inventors: Paul Pevsner; Frederick Naftolin; Douglas Miller; Dean Hillman; Brian Stall; Steven Wishnies. Assignee: New York University.

Covers the use of post source decay or collision induced dissociation direct tissue MALDI mass spec for identification of biological molecules in a tissue or cell sample.


US Patent No. 8,518,654. Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect. Inventors: Koji Ueda; Hidewaki Nakagawa; Atsuhiko Toyama; Taka-Aki Sato. Assignees: Riken; Shimadzu

Covers a protein biomarker for diagnosis lung cancer.


US Patent No. 8,518,652. Truncated proteins as cancer markers. Inventors: George Gorodeski; Ying-Hong Feng; Xin Li. Assignee: Uniformed Services University of the Health Sciences, an Institution of Higher Learning within the Department of Defense; The Henry M. Jackson Foundation for the Advancement of Military Medicine

Covers methods for detecting or treating cancers by detecting truncated forms of the P2X.7 protein.


US Patent No. 8,518,651. Marker for identification of tissue type of epithelial ovarian cancer, and method for determination of the occurrence of epithelial ovarian cancer based on tissue type by using the marker. Inventors: Taka-aki Sato; Atsuhiko Toyama; Takashi Shimada; Tetsuyoshi Sugita; Daisuke Aoki; Atsushi Suzuki; Nobuyuki Susumu; Hiroyuki Nomura. Assignee: Shimadzu; Keio University

Covers a method for the identification of the morbidity of epithelial ovarian cancer based on tissue-type using molecular typing based on protein expression.


US Patent No. 8,515,686. Detection and quantification of polypeptides using mass spectrometry. Inventors: Keith Ashman; Matthew McKay; James Sherman; Mark Molloy. Assignee: Macquarie University

Covers a method for detecting and quantifying polypeptides using mass spectrometry.


US Patent No. 8,512,959. Monoclonal antibody based biomarker discovery and development platform. Inventors: Laszlo Takacs; Andras Guttman; William Hancock; Barry Karger; Manuel Duval; Patrick Berna. Assignee: Northeastern University

Covers a method of monoclonal antibody-based biomarker discovery that integrates analyte collection, hybridoma screening, and nanovolume mass spectrometry in a screening system that can significantly speed traditional protein biomarker discovery and development.


US Patent No. 8,507,845. Membrane detector for time-of-flight mass spectrometry. Inventors: Robert Blick; Jonghoo Park. Assignee: Wisconsin Alumni Research Foundation.

Covers methods and devices for detecting and analyzing analytes by using a thin membrane-based detector as a transducer for converting the kinetic energies of analytes into a field emission signal via excitation of mechanical vibrations in an electromechanically biased membrane by generation of a thermal gradient.


US Patent No. 8,507,291. Detergent removal from protein samples prior to mass spectrometry analysis. Inventors: Babu Antharavally; Krishna Mallia; Ashok Salunkhe. Assignee: Pierce Biotechnology.

Covers use of a cyclodextrin polymer resin to remove detergents from samples prior to mass spec analysis.


US Patent No. 8,507,287. Mesoporous metal oxide materials for phosphoproteomics. Inventors: Song Jin; Ying Ge; Cory Nelson; Qingge Xu. Assignee: Wisconsin Alumni Research Foundation.

Covers use of metal oxide mesoporous materials to selectively and reversibly bind with phosphorylated compounds for enrichment of phosphorylated proteins and peptides.


US Patent No. 8,506,803. Integrated electrospray ionization emitter and detection cell for parallel measurements by fluorescence and mass spectrometry. Inventors: Jason Russell; Joshua Coon; Ryan Hilger; Lloyd Smith; Daniel Ladror; Robert Shortreed; Mark Scalf; Assignee: Wisconsin Alumni Research Foundation.

Covers an integrated mass spectrometer electrospray emitter and fluorescence detector that allows improved volumetric measurements of separate components from a liquid chromatography column.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.