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Invitrogen to Use Genisphere's Signal Amplification Technology in miRNA Kits

NEW YORK (GenomeWeb News) – Invitrogen announced today that it has licensed exclusive rights to use Genisphere’s 3DNA dendrimer signal amplification technology along with its own Alexa Fluor fluorescent dyes in the new NCode Rapid miRNA Labeling System.
Genisphere’s technology is based on highly branched DNA structures that serve as scaffolds for multitudes of fluorescent dyes. According to a joint statement from the firms, researchers using the technology can start with a total RNA sample as little as 250 nanograms, which eliminates the need to purify the microRNA sample before labeling. They added that the NCode Rapid miRNA Labeling System can reliably detect two to 10 copies of microRNA per cell.
“Because microRNAs play a significant role in cancer and in the differentiation of stem cells, discoveries resulting from experiments in those areas could potentially expedite the diagnostics applications of microRNA biomarkers in disease,” said Peter Welch, director of research and development, Gene Expression Profiling, at Invitrogen.
Terms of the alliance were not disclosed.